H2N2V1, 1957, Analysis, bibRecord, 000206

Antigenic variation in current influenza A viruses: evidence for a high frequency of antigenic `drift' for the Hong Kong virus

Identifieur interne : 000206 ( 1957/Analysis ); précédent : 000205; suivant : 000207

Antigenic variation in current influenza A viruses: evidence for a high frequency of antigenic `drift' for the Hong Kong virus

Auteurs : G. C. Schild ; J. S. Oxford ; W. R. Dowdle ; M. Coleman ; M. S. Pereira ; P. Chakraverty

Source :

Bulletin of the World Health Organization [ 0042-9686 ] ; 1974.

RBID : PMC:2366252

Descripteurs français

KwdFr :
- Anticorps antiviraux (analyse), Antigènes viraux (analyse), Grippe humaine (immunologie), Hong Kong, Humains, Hémagglutinines virales (analyse), Immunodiffusion, Orthomyxoviridae (immunologie), Réaction antigène-anticorps, Réactions croisées, Sialidase (immunologie), Sérotypage, Tests d'inhibition de l'hémagglutination, Vaccins antigrippaux, Virus de la grippe A (immunologie).
MESH :
- analyse : Anticorps antiviraux, Antigènes viraux, Hémagglutinines virales.
- immunologie : Grippe humaine, Orthomyxoviridae, Sialidase, Virus de la grippe A.
- Hong Kong, Humains, Immunodiffusion, Réaction antigène-anticorps, Réactions croisées, Sérotypage, Tests d'inhibition de l'hémagglutination, Vaccins antigrippaux.
Wicri :
- geographic : Hong Kong.

English descriptors

KwdEn :
- Antibodies, Viral (analysis), Antigen-Antibody Reactions, Antigens, Viral (analysis), Cross Reactions, Hemagglutination Inhibition Tests, Hemagglutinins, Viral (analysis), Hong Kong, Humans, Immunodiffusion, Influenza A virus (immunology), Influenza Vaccines, Influenza, Human (immunology), Neuraminidase (immunology), Orthomyxoviridae (immunology), Serotyping.
MESH :
- chemical , analysis : Antibodies, Viral, Antigens, Viral, Hemagglutinins, Viral.
- chemical , immunology : Neuraminidase.
- geographic : Hong Kong, Influenza Vaccines.
- immunology : Influenza A virus, Influenza, Human, Orthomyxoviridae.
- Antigen-Antibody Reactions, Cross Reactions, Hemagglutination Inhibition Tests, Humans, Immunodiffusion, Serotyping.

Abstract

A new antigenic variant of the Hong Kong (H3N2) subtype of influenzavirus type A is described. The variant, A/Port Chalmers/1/73 (H3N2), was first isolated in Australasia in the autumn of 1973 and subsequently became the predominant influenza A variant in most areas of the world, replacing the previously prevalent strain A/England/42/72 (H3N2). The 1973 variant shows antigenic differences from former Hong Kong variants in both haemagglutinin and neuraminidase antigens. The application of immuno-double-diffusion tests and single-radial-diffusion tests in the antigenic analysis of new variants of the influenzavirus is also described. It is emphasized that since new variants of the Hong Kong virus have appeared in the successive years 1971, 1972, and 1973, the annual frequency of antigenic “drift” for the Hong Kong virus is higher than was recorded for the “Asian” influenzavirus (H2N2) in the first 5 years of the latter's prevalence from 1957 to 1962, during which period little antigenic variation occurred.

ImagesFig. 1Fig. 2Fig. 3

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2366252

PubMed: 4218138
PubMed Central: 2366252

Affiliations:

Links to Exploration step

PMC:2366252

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<front><div type="abstract" xml:lang="en"><p>A new antigenic variant of the Hong Kong (H3N2) subtype of influenzavirus type A is described. The variant, A/Port Chalmers/1/73 (H3N2), was first isolated in Australasia in the autumn of 1973 and subsequently became the predominant influenza A variant in most areas of the world, replacing the previously prevalent strain A/England/42/72 (H3N2). The 1973 variant shows antigenic differences from former Hong Kong variants in both haemagglutinin and neuraminidase antigens. The application of immuno-double-diffusion tests and single-radial-diffusion tests in the antigenic analysis of new variants of the influenzavirus is also described. It is emphasized that since new variants of the Hong Kong virus have appeared in the successive years 1971, 1972, and 1973, the annual frequency of antigenic “drift” for the Hong Kong virus is higher than was recorded for the “Asian” influenzavirus (H2N2) in the first 5 years of the latter's prevalence from 1957 to 1962, during which period little antigenic variation occurred.</p>
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Antigenic variation in current influenza A viruses: evidence for a high frequency of antigenic `drift' for the Hong Kong virus

Antigenic variation in current influenza A viruses: evidence for a high frequency of antigenic `drift' for the Hong Kong virus

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration H2N2
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